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Estriol (E3), sold under the brand name Ovestin among others, is an estrogen medication and naturally occurring steroid hormone which is used in menopausal hormone therapy. [12] [4] [6] [13] It is also used in veterinary medicine as Incurin to treat urinary incontinence due to estrogen deficiency in dogs.
It is a veterinary drug used to reverse sedation in dogs and deer. While yohimbine behaves as an aphrodisiac in some mammals, it does not do so in humans. It has been prescribed as a treatment for erectile dysfunction , although its reported clinical benefits were modest and it has largely been superseded by the PDE5 inhibitor class of drugs.
Estrogen appears to have a protector effect on atherosclerosis: it lowers LDL and triglycerides, it raises HDL levels and has endothelial vasodilatation properties plus an anti-inflammatory component. Research is underway to determine if risks of estrogen supplement use are the same for all methods of delivery.
Some studies have found that some concentrations of isoflavones may have effects on intestinal cells. At low doses, genistein acted as a weak estrogen and stimulated cell growth; at high doses, it inhibited proliferation and altered cell cycle dynamics. This biphasic response correlates with how genistein is thought to exert its effects. [47]
Researchers found that rats given synthetic estrogen exhibited more behaviors associated with anxiety, compared to a more natural estrogen used in a more modern form of the contraceptive pill.
Estetrol is a major estrogen in the body. [ 1 ] [ 2 ] In contrast to estrone and estradiol, estetrol is a native estrogen of fetal life. Estetrol is produced exclusively by the fetal liver [ 1 ] and is found in detectable levels only during pregnancy, with relatively high levels in the fetus and lower levels in the maternal circulation.