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Tricyclic antidepressant overdose is poisoning caused by excessive medication of the tricyclic antidepressant (TCA) type. Symptoms may include elevated body temperature , blurred vision, dilated pupils , sleepiness, confusion, seizures , rapid heart rate , and cardiac arrest . [ 1 ]
Due to the possibility of unblinding by side effects, it was unclear whether TCAs had a genuine antidepressant effect or whether the benefits were merely due to amplified placebo effects. [11] TCAs had a higher rate of serious adverse effects than placebo, but this did not reach statistical significance (OR Tooltip odds ratio = 2.78; 95% CI: 2. ...
Since some tricyclic antidepressants (TCAs) and monoamine oxidase inhibitors (MAOIs) can cause harmful interactions if used within 14 days of starting treatment with other antidepressants, you may ...
Tricyclic antidepressants are occasionally used as second-line antidepressants when newer treatments such as SSRIs or SNRIs don’t work or cause unwanted side effects. Since some tricyclic ...
An older type of antidepressant, TCAs also alter your levels of neurotransmitters. Tricyclic antidepressants aren’t used as often today because they can cause more side effects and drug ...
The symptoms and the treatment of an overdose are generally the same as for the other tricyclic antidepressants, including anticholinergic effects, serotonin syndrome and adverse cardiac effects. TCAs, particularly nortriptyline, have a relatively narrow therapeutic index, which increase the chance of an overdose (both accidental and intentional).
Desipramine, sold under the brand name Norpramin among others, is a tricyclic antidepressant (TCA) used in the treatment of depression. [8] It acts as a relatively selective norepinephrine reuptake inhibitor, though it does also have other activities such as weak serotonin reuptake inhibitory, α 1-blocking, antihistamine, and anticholinergic effects.
Tricyclic antidepressants (TCAs) Bupropion. Let’s get to know each one better. stefanamer/istockphoto. SSRIs. The most commonly prescribed SSRIs include: Escitalopram (Lexapro)
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