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Malate is acted on by malate dehydrogenase to become oxaloacetate, producing a molecule of NADH. After that, oxaloacetate will be recycled to aspartate, as transaminases prefer these keto acids over the others. This recycling maintains the flow of nitrogen into the cell. Relationship of oxaloacetic acid, malic acid, and aspartic acid
Oxalic acid has an oral LD Lo (lowest published lethal dose) of 600 mg/kg. [65] It has been reported that the lethal oral dose is 15 to 30 grams. [66] The toxicity of oxalic acid is due to kidney failure caused by precipitation of solid calcium oxalate. [67] Oxalate is known to cause mitochondrial dysfunction. [68]
Nearly one in five adults “who say they have no personal or family history of heart attack or stroke,” reported in the survey that they “routinely” took a low-dose aspirin, with 10% saying ...
Acceptable daily intake or ADI is a measure of the amount of a specific substance (originally applied for a food additive, later also for a residue of a veterinary drug or pesticide) in food or drinking water that can be ingested (orally) daily over a lifetime without an appreciable health risk. [1]
The therapeutic index (TI; also referred to as therapeutic ratio) is a quantitative measurement of the relative safety of a drug with regard to risk of overdose.It is a comparison of the amount of a therapeutic agent that causes toxicity to the amount that causes the therapeutic effect. [1]
Adults (18–70 years): 15 mcg or 600 IU. Older adults (over 70 years): 20 mcg or 800 IU. Sources of vitamin D. Vitamin D can be obtained from several sources. ... Vitamin D supplement dosage.