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The free radical mechanism to treat certain types of cancers extends beyond enediynes. Tirapazamine generates a free radical under anoxic conditions instead of the trigger mechanism of an enediyne. The free radical then continues on to cleave DNA in a similar manner to 1,4-didehydrobenzene in order to treat cancerous cells.
Oxidative stress mechanisms in tissue injury. Free radical toxicity induced by xenobiotics and the subsequent detoxification by cellular enzymes (termination).. Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage. [1]
The highly reactive free radicals can recombine back to original molecules, or initiate a chain of free-radical polymerization reactions with other molecules, yielding compounds with increasing molecular weight. These high molecular weight compounds then precipitate from gaseous phase, forming conductive or non-conductive deposits on the ...
The association between fat cell volume and changes in body weight, BMI, and total body fat remained significant when the researchers adjusted for age, physical activity, length of follow-up, and ...
The team later assessed the concentration of these isotopes in urine samples, which correlates with the body's daily carbon dioxide production and, consequently, daily energy expenditure. [ 8 ] Results indicated that Hadza women burned an average of 1,877 calories per day, which was nearly the same as the 1,864 calories burned daily by women in ...
The free radical theory of aging states that organisms age because cells accumulate free radical damage over time. [1] A free radical is any atom or molecule that has a single unpaired electron in an outer shell. [2] While a few free radicals such as melanin are not chemically reactive, most biologically relevant free radicals are highly ...
Any minor water weight usually subsides as your body adapts to a routine, and being well-hydrated is actually connected with weight loss and reduced waist circumference, per a 2021 study in ...
I set a goal to transform 50 percent of my body weight into muscle within a year. So, I took Orangetheory circuit training classes three times a week, working on both strength training and cardio.