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The predominant symptom is peripheral sensory neuropathy [26] [4] [6] [27] that is experienced as numbness, pins-and-needles and burning sensations (paresthesia) in a patient's limbs on both sides of their body.
The adults, who were the parents of three of the adolescents, all had symptoms during adolescence but were asymptomatic as adults. [5] Seeing as NTS is believed to have an autosomal dominant genetic pattern, the many differences observed regarding the symptoms of NTS can be explained as variable expressivity. Some of these differences include ...
Paresthesia, also known as pins and needles, is an abnormal sensation of the skin (tingling, pricking, chilling, burning, numbness) with no apparent physical cause. [1] Paresthesia may be transient or chronic, and may have many possible underlying causes. [ 1 ]
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Hypoesthesia or numbness is a common side effect of various medical conditions that manifests as a reduced sense of touch or sensation, or a partial loss of sensitivity to sensory stimuli. In everyday speech this is generally referred to as numbness.
The symptoms can be recalled by the mnemonic "CATs go numb" - convulsions, arrhythmias, tetany, and numbness in the hands and feet and around the mouth. [ citation needed ] Petechiae which appear as on-off spots, then later become confluent, and appear as purpura (larger bruised areas, usually in dependent regions of the body).
Usually bilaterally located on the tongue or less commonly the palate, lips or lower alveolar mucosa: Onset: Pain is chronic, and rarely spontaneously remits Character: Burning, scalded or tingling. Sometimes the sensation is described as 'discomfort', 'tender', 'raw' and 'annoying' rather than pain or burning. Radiation: Associations
When on the lips, it commonly looks like a persistent crusting ulcer that does not heal, and slowly grows. [7] Other symptoms may include difficult or painful swallowing, new lumps or bumps in the neck, a swelling in the mouth, or a feeling of numbness in the mouth or lips. [8] Risk factors include tobacco and alcohol use.