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22227 Ensembl ENSG00000109424 ENSMUSG00000031710 UniProt P25874 P12242 RefSeq (mRNA) NM_021833 NM_009463 RefSeq (protein) NP_068605 NP_033489 Location (UCSC) Chr 4: 140.56 – 140.57 Mb Chr 8: 84.02 – 84.03 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Thermogenin (called uncoupling protein by its discoverers and now known as uncoupling protein 1, or UCP1) is a mitochondrial ...
the complete release of respiratory control; the substitution of all coupled processes (ATP synthesis, transhydrogenation, reverse electron flow, active transport of cations, etc.) by a cyclic proton transport mediated by the uncoupler; the elimination of all protonic and cationic gradients generated across the mitochondrial or prokaryotic membrane
In practice the efficiency may be even lower because the inner membrane of the mitochondria is slightly leaky to protons. [11] Other factors may also dissipate the proton gradient creating an apparently leaky mitochondria. An uncoupling protein known as thermogenin is expressed in some cell types and is a channel that can transport protons.
Although it was originally thought to play a role in non-shivering thermogenesis, obesity, diabetes and atherosclerosis, it now appears that the main function of UCP2 is the control of mitochondria-derived reactive oxygen species. [8] Chromosomal order is 5'-UCP3-UCP2-3'. [9] Mitochondrial Uncoupling Protein 2
The body processes some foods, like simple sugars, more quickly, thus raising blood sugar levels faster and putting more strain on the pancreas to produce the insulin needed to take care of that ...
A 2012 study in Plant Foods for Human Nutrition suggests that the high antioxidant levels in pomegranate juice can help lower blood pressure. Try it: Add the juicy seeds to your favorite dishes ...
Many endothermic plant species rely on alternative oxidase (AOX), which is an enzyme in the mitochondria organelle and is a part of the electron transport chain. [9] The reduction of mitochondrial redox potential by alternative oxidase increases unproductive respiration.
Limiting certain foods may also help in controlling high blood pressure. First, individuals with hypertension are recommended to limit sodium intake to about 1,500 milligrams or less per day.