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Epithelial basement membrane dystrophy (EBMD) is a disorder of the eye that can cause pain and dryness. EBMD, also known as map-dot-fingerprint dystrophy and Cogan microcystic epithelial dystrophy , is a corneal epithelial disease that may result in recurrent corneal erosions , irregular corneal astigmatism , and decreased vision.
Most cases of recurrent corneal erosion are acquired. There is often a history of recent corneal injury, such as corneal abrasion or ulcer, but also may be idiopathic or due to corneal dystrophy or corneal disease. In other words, one may develop corneal erosions as a result of another disorder, such as epithelial basement membrane dystrophy ...
Lattice dystrophy starts as fine branching linear opacities in Bowman's layer in the central area and spreads to the periphery. Recurrent corneal erosions may occur. The hallmark of Schnyder corneal dystrophy is the accumulation of crystals within the corneal stroma which cause corneal clouding typically in a ring-shaped fashion. [citation needed]
Although people with lattice dystrophy have an excellent chance for a successful corneal transplantation, the disease may also arise in the donor cornea in as little as three years. In one study, about half of the transplant patients with lattice dystrophy had a recurrence of the disease between two and 26 years after the operation.
The way in which the dots form in some of the white dot syndromes has been reported. The dot appears as a small granuloma which is composed of lymphocytes and macrophages. The lesion may occur within the choroid, between Bruch's membrane and retinal pigment epithelium, or between the retinal pigment epithelium and photoreceptors. [7]
Fleck corneal dystrophy, also known as Francois-Neetens speckled corneal dystrophy, is a rare form of corneal dystrophy. It is caused by mutations in PIKFYVE gene. Small opacities, some of which resemble "flecks", are scattered in the stroma of the patients. Other opacities look more like snowflakes or clouds.
There are 27 major trauma centres within NHS England, in three categories: adult and children; adult only; and children only. [3] At first a small number of pilot sites were trialled. All major trauma centres in England operate within local trauma networks, ensuring patients are treated at the most appropriate place for their injuries, but ...
Oculopharyngeal muscular dystrophy (OPMD) is a rare form of muscular dystrophy with symptoms generally starting when an individual is 40 to 50 years old. It can be autosomal dominant neuromuscular disease or autosomal recessive. The most common inheritance of OPMD is autosomal dominant, which means only one copy of the mutated gene needs to be ...