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Mucins (/ ˈ m juː s ɪ n /) are a family of high molecular weight, heavily glycosylated proteins (glycoconjugates) produced by epithelial tissues in most animals. [1] Mucins' key characteristic is their ability to form gels; therefore they are a key component in most gel-like secretions, serving functions from lubrication to cell signalling to forming chemical barriers. [1]
It is one of the five gel-forming mucins. MUC-5B can be found in whole saliva, normal lung mucus, and cervical mucus. In some diseases, such as COPD, chronic rhinosinusitis (CRS), and H. pylori-associated gastric disease, the gene has been found to be upregulated, and this may be related to the pathogenesis of these conditions. [9]
The major mucins secreted – MUC5AC and MUC5B - are large polymers that give the mucus its rheologic or viscoelastic properties. [7] [4] MUC5AC is the main gel-forming mucin secreted by goblet cells, in the form of threads and thin sheets. MUC5B is a polymeric protein secreted from submucosal glands and some goblet cells, and this is in the ...
17831 Ensembl ENSG00000198788 ENSMUSG00000025515 UniProt Q02817 n/a RefSeq (mRNA) NM_002457 NM_023566 RefSeq (protein) NP_002448 n/a Location (UCSC) Chr 11: 1.07 – 1.11 Mb Chr 7: 141.28 – 141.31 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Mucin 2, oligomeric mucus gel-forming, also known as MUC2, is a protein that in humans is encoded by the MUC2 gene. Function This gene ...
Mucin-5AC (MUC-5AC) is a protein that is encoded by the MUC5AC gene in humans. [5] [6] [7]MUC-5AC is a large gel-forming glycoprotein.In the respiratory tract, it protects against infection by binding to inhaled pathogens, which are subsequently removed by mucociliary clearance.
The two main components of the gel are mucins and water, with the mucins forming the backbone of the mucous. [4] Mucin originates from the mucus secretions from submaxillary glands, which are salivary glands that are located under the floor of the mouth. The secreted mucin assists in digestion by coating the bolus such that it travels easily ...
Mucin 6, oligomeric mucus/gel-forming, also known as MUC6, is a human gene encoding a protein of the same name. [5] MUC6, along with MUC2, MUC5AC, and MUC5B, is located within the 11p15 chromosomal locus of chromosome 11. MUC6, along with MUC1, is expressed in normal pancreases. [6]
Goblet cells are simple columnar epithelial cells that secrete gel-forming mucins, like mucin 2 in the lower gastrointestinal tract, and mucin 5AC in the respiratory tract. [1] The goblet cells mainly use the merocrine method of secretion, secreting vesicles into a duct, but may use apocrine methods, budding off their secretions, when under ...