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The blood–air barrier or air–blood barrier, (alveolar–capillary barrier or membrane) exists in the gas exchanging region of the lungs. It exists to prevent air bubbles from forming in the blood , and from blood entering the alveoli .
The membrane has several layers – a layer of alveolar lining fluid that contains surfactant, the epithelial layer and its basement membrane; a thin interstitial space between the epithelial lining and the capillary membrane; a capillary basement membrane that often fuses with the alveolar basement membrane, and the capillary endothelial membrane.
The primary purpose of the respiratory system is the equalizing of the partial pressures of the respiratory gases in the alveolar air with those in the pulmonary capillary blood (Fig. 11). This process occurs by simple diffusion , [ 22 ] across a very thin membrane (known as the blood–air barrier ), which forms the walls of the pulmonary ...
A capillary is a small blood vessel, from 5 to 10 micrometres in diameter, and is part of the microcirculation system. Capillaries are microvessels and the smallest blood vessels in the body. They are composed of only the tunica intima (the innermost layer of an artery or vein), consisting of a thin wall of simple squamous endothelial cells. [2]
The alveolar and pulmonary capillary gases equilibrate across the thin blood–air barrier. [34] [68] [69] This thin membrane (about 0.5 –2 μm thick) is folded into about 300 million alveoli, providing an extremely large surface area (estimates varying between 70 and 145 m 2) for gas exchange to occur. [68] [70]
Diffuse alveolar damage (DAD) is a histologic term used to describe specific changes that occur to the structure of the lungs during injury or disease. Most often DAD is described in association with the early stages of acute respiratory distress syndrome ( ARDS ). [ 1 ]
The conducting zone also functions to offer a low resistance pathway for airflow. It provides a major defense role in its filtering abilities. The respiratory zone includes the respiratory bronchioles, alveolar ducts, and alveoli, and is the site of oxygen and carbon dioxide exchange with the blood. The respiratory bronchioles and the alveolar ...
First CO crosses the alveolar capillary membrane (represented by ) and then CO combines with the hemoglobin in capillary red blood cells at a rate times the volume of capillary blood present (). [13] Since the steps are in series, the conductances add as the sum of the reciprocals: