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Cocaine dependence is a neurological disorder that is characterized by withdrawal symptoms upon cessation from cocaine use. [1] It also often coincides with cocaine addiction which is a biopsychosocial disorder characterized by persistent use of cocaine and/or crack despite substantial harm and adverse consequences.
The goal of addiction research is to find ways to prevent and reverse the effects of addiction on the brain. Theoretically, if the structural changes in the brain associated with addiction can be blocked, then the negative behaviors associated with the disease should never develop.
These transcription factors have been shown to play a role in the short-term and long-term adaptive changes in the brain. CREB has been implicated in learning, memory, and depression and enriched in cocaine users within the nucleus accumbens. CREB seems to upregulate many genes in its pathway within the reward regions of the brain.
Cocaine crosses the blood–brain barrier via a ... Repeated use is likely to result in addiction. ... by long-term users, is the risk of ill effects or damage caused ...
The reasons believed to cause the increased risk of suicide include the long-term abuse of alcohol and other drugs causing physiological distortion of brain chemistry as well as the social isolation. [25] Another factor is the acute intoxicating effects of the drugs may make suicide more likely to occur.
Being vulnerable to addiction means there is a factor that makes one individual more likely to develop an addiction than another individual. Additionally, many in the science community agree that addiction is not simply just a result of desensitized neural receptors but also a corollary of long-term associated memories (or cues) of substance ...
Benzodiazepines are not intended for long-term use because of the potential for addiction. So, after a few weeks, your healthcare provider will likely wean you off of any benzodiazepines.
Addiction recovery is a long process and relapse is likely to occur during this process. [85] Relapse can occur at any time during the recovery process, so recognizing the warning signs of relapse is important. Some of these warning signs in the recovering individual may include increased use of other drugs (eg.