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“Absolutely no study suggests cannabis use as a viable therapeutic strategy for anxiety and depression,” he wrote. “ … Ongoing use that is more than occasional would likely hurt ...
Here’s where science currently stands on the use of marijuana for pain, sleep, anxiety, muscle spasms and other ailments — the results may surprise you. How marijuana impacts pain, sleep ...
In areas where marijuana becomes legal and easier to access, Volkow’s concern is the ease with which products can be mixed, leading to a high total dose of marijuana consumed.
The psychoactive component of cannabis, tetrahydrocannabinol (THC) is not effective in treating emotion-regulation and anxiety-related symptoms. [20] Conversely, THC has been empirically related to an increase anxiety symptoms through impacts on neurological areas impacting serotonin, noradrenalin, GABA and glutamate. [20] [21] [22] [23]
Some report anxiety only after not smoking cannabis for a prolonged period of time. [38] Inexperience and use in an unfamiliar environment are major contributing factors to this anxiety. Cannabidiol (CBD), another cannabinoid found in cannabis, has been shown to mitigate THC's adverse effects, including anxiety.
People sometimes use cannabis to cope with their anxiety, and cannabis withdrawal can lead to symptoms of anxiety. [58] Buspirone, a serotonin 5-HT 1A receptor partial agonist, has shown limited efficacy for treating anxiety in people with cannabis use disorder, though there may be better efficacy in males than in females. [58]
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