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Diffuse large B-cell lymphoma (DLBCL) is a cancer of B cells, a type of lymphocyte that is responsible for producing antibodies.It is the most common form of non-Hodgkin lymphoma among adults, [1] with an annual incidence of 7–8 cases per 100,000 people per year in the US and UK.
Patients with MYC-R have inferior outcomes and can be classified as single-hit, when they only have MYC-R; as double hit when the rearrangement is accompanied by a translocation of BCL2 or BCL6; and as triple hit when MYC-R includes both BCL2 and BCL6. Double and triple hit lymphoma have been recently classified as high-grade B-cell lymphoma ...
Burkitt lymphoma is a very aggressive cancer, which can quickly metastasize and spread throughout the body if the cancer is not treated quickly. If the patient is left untreated, or if treatment is initiated too late, Burkitt lymphoma can be fatal. [4] Burkitt lymphoma in children often has a better prognosis than the same cancer in an adult.
Lymphoma is a group of blood and lymph tumors that develop from lymphocytes ... Burkitt lymphoma, for example, is a high-grade tumour known to double within days, ...
The two-hit hypothesis, also known as the Knudson hypothesis, is the hypothesis that most tumor suppressor genes require both alleles to be inactivated, either through mutations or through epigenetic silencing, to cause a phenotypic change. [1]
Apoptosis is one of the major mechanisms of cell death targeted by cancer therapies. Reduced susceptibility to apoptosis increases the resistance of cancer cells to radiation and cytotoxic agents. B-cell lymphoma-2 (Bcl-2) family members create a balance between pro and anti-apoptotic proteins. Pro-apoptotic proteins include Bax and Bak.
She presented herself as a young woman and mother of two battling an aggressive blood cancer, Hodgkin’s lymphoma — who, despite her devastating diagnosis, was not giving up, ...
Micrograph showing Hodgkin's lymphoma, a type of B cell lymphoma that is usually considered separate from other B cell lymphomas. Field stain. CT scan of primary B cell lymphoma in the left ilium, as diffuse cortical and trabecular thickening of the hemipelvis, mimicking Paget's disease. [2] There are numerous kinds of lymphomas involving B cells.
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