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In response, Congress created a Cancer Chemotherapy National Service Center (CCNSC) at the NCI in 1955. [14] This was the first federal programme to promote drug discovery for cancer – unlike now, most pharmaceutical companies were not yet interested in developing anticancer drugs.
1966 – Taxol, anti-cancer compound, isolated from the yew plant; 1967 – Camptothecin, anti-cancer compound, isolated from the Camptotheca acuminata, the Chinese Happy Tree, which was used as a cancer treatment in traditional Chinese medicine. [23] It is the source of chemotherapy drugs: topotecan and irinotecan.
AOH1996 was created to ... or in combination with one or more other chemotherapy drugs. Although the press described it as a "miracle drug" that would cure cancer ...
As most chemotherapy drugs kill cancer cells in this manner, defective apoptosis allows survival of these cells, making them resistant. Many chemotherapy drugs also cause DNA damage, which can be repaired by enzymes in the cell that carry out DNA repair. Upregulation of these genes can overcome the DNA damage and prevent the induction of apoptosis.
Its top performer was the lung cancer drug Tagrisso, which had revenues of $5 billion and is a targeted therapy for lung cancer patients with a certain mutation taken as a convenient once-daily pill.
Chemotherapy for NSCLC usually includes combination of two drugs (chemotherapy doublet), with one of the agents is cisplatin or carboplatin. In 2002, Schiller at al. published in the New England Journal of Medicine, a study that compared four chemotherapy regimens for advanced NSCLC, cisplatin and paclitaxel, cisplatin and gemcitabine, cisplatin and docetaxel, and carboplatin and paclitaxel. [14]
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