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In light of recent evidence, olanzapine (Zyprexa) has been FDA approved as an effective monotherapy for the maintenance of bipolar disorder. [22] A head-to-head randomized control trial in 2005 has also shown olanzapine monotherapy to be just as effective and safe as lithium in prophylaxis. [23]
FDA approved for bipolar disorder maintenance therapy, not for acute mood problems like depression or mania/hypomania. [10] The usual target dose is 100–200 mg daily, titrated to by 25 mg increments every 2 weeks. [11] Lamotrigine can cause Stevens–Johnson syndrome, a very rare but potentially fatal skin condition. [10] Carbamazepine
June 2003 — approved for maintenance treatment of bipolar II disorder; the first such medication since lithium. [citation needed] January 2004 — for use as monotherapy for the treatment of partial seizures in adult patients when converting from the anti-epileptic drug valproate (including valproic acid) [citation needed]
Lithium is the only medication approved by the FDA for ... in long-term maintenance to prevent ... resistant bipolar disorder. [163] [164] Guidelines to the ...
Lumateperone was approved for medical use in the United States in December 2019 with an initial indication for schizophrenia, [4] [5] and became available in February 2020. [2] It has since demonstrated efficacy in bipolar depression and received FDA approval in December 2021 for depressive episodes associated with both bipolar I and II disorders.
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