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An example of a Kaplan–Meier plot for two conditions associated with patient survival. The Kaplan–Meier estimator, [1] [2] also known as the product limit estimator, is a non-parametric statistic used to estimate the survival function from lifetime data. In medical research, it is often used to measure the fraction of patients living for a ...
The graphs below show examples of hypothetical survival functions. The x-axis is time. The y-axis is the proportion of subjects surviving. The graphs show the probability that a subject will survive beyond time t. Four survival functions. For example, for survival function 1, the probability of surviving longer than t = 2 months is 0.37. That ...
Paul Meier (July 24, 1924 – August 7, 2011) [1] was a statistician who promoted the use of randomized trials in medicine. [2] [3]Meier is known for introducing, with Edward L. Kaplan, the Kaplan–Meier estimator, [4] [5] a method for measuring how many patients survive a medical treatment from one duration to another, taking into account that the sampled population changes over time.
For example, one might use it to fit an isotonic curve to the means of some set of experimental results when an increase in those means according to some particular ordering is expected. A benefit of isotonic regression is that it is not constrained by any functional form, such as the linearity imposed by linear regression , as long as the ...
It is used in survival theory, reliability engineering and life insurance to estimate the cumulative number of expected events. An "event" can be the failure of a non-repairable component, the death of a human being, or any occurrence for which the experimental unit remains in the "failed" state (e.g., death) from the point at which it changed on.
30 samples of 10 dots of random color (blue or red) are observed. On each sample, a two-tailed binomial test of the null hypothesis that blue and red are equally probable is performed. The first row shows the possible p-values as a function of the number of blue and red dots in the sample.
The sample mean is thus more efficient than the sample median in this example. However, there may be measures by which the median performs better. For example, the median is far more robust to outliers, so that if the Gaussian model is questionable or approximate, there may advantages to using the median (see Robust statistics).
For example, if the data from the two samples have exponential distributions. If is the logrank statistic, is the number of events observed, and ^ is the estimate of the hazard ratio, then ^ /. This relationship is useful when two of the quantities are known (e.g. from a published article), but the third one is needed.