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[1] [2] It is the derivative of 2-phenylmorpholine with a 2-naphthalene ring instead of a phenyl ring. [1] [2] Naphthylmorpholine is a close analogue of naphthylmetrazine (PAL-704; a naphthalene analogue of phenmetrazine), but lacks naphthylmetrazine's methyl group at the 3 position of the morpholine ring. [1] [2] The drug is a potent monoamine ...
In February, Invitae filed for voluntary Chapter 11 protection in a U.S. bankruptcy court and said that it intended to pursue a sale process. Invitae's estimated assets were in the $500 million ...
2-Naphthylaminopropane, one of the more well-known naphthylethylamines. 1-Naphthylaminopropane, a lesser-known naphthylethylamine.. The substituted naphthylethylamines are a class of chemical compounds based on naphthalene.
Invitae Corp. is a biotechnology company that was created as a subsidiary of Genomic Health in 2010 and then spun-off in 2012. [2] In 2017, Invitae acquired Good Start Genetics and CombiMatrix. [3] [4] In 2020, Invitae announced the acquisition of ArcherDX for $1.4 billion. [5]
The Softbank-backed company is working with FTI Consulting and law firm Kirkland & Ellis to explore strategic options, including bankruptcy, to address $1.5 billion of debt on its bala
Stromal interaction molecule 1 is a protein that in humans is encoded by the STIM1 gene. [5] [6] [7] STIM1 has a single transmembrane domain, and is localized to the endoplasmic reticulum, and to a lesser extent to the plasma membrane. [8] Even though the protein has been identified earlier, its function was unknown until recently.
[1] Neurotransmitters are released from synaptic vesicles into the synaptic cleft where they are able to interact with neurotransmitter receptors on the target cell. Some neurotransmitters are also stored in large dense core vesicles. [2] The neurotransmitter's effect on the target cell is determined by the receptor it binds to.
Naphthylaminopropane is a serotonin–norepinephrine–dopamine releasing agent (SNDRA). [3] [4] Its EC 50 Tooltip half-maximal effective concentration values for induction of monoamine release are 3.4 nM for serotonin, 11.1 nM for norepinephrine, and 12.6 nM for dopamine.