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RNA helicases and DNA helicases can be found together in all the helicase superfamilies except for SF6. [58] [59] All the eukaryotic RNA helicases that have been identified up to date are non-ring forming and are part of SF1 and SF2. On the other hand, ring-forming RNA helicases have been found in bacteria and viruses. [56]
Within eukaryotes, DNA replication is controlled within the context of the cell cycle. As the cell grows and divides, it progresses through stages in the cell cycle; DNA replication takes place during the S phase (synthesis phase). The progress of the eukaryotic cell through the cycle is controlled by cell cycle checkpoints.
In order to preserve genetic information during cell division, DNA replication must be completed with high fidelity. In order to achieve this task, eukaryotic cells have proteins in place during certain points in the replication process that are able to detect any errors during DNA replication and are able to preserve genomic integrity.
The minichromosome maintenance protein complex (MCM) is a DNA helicase essential for genomic DNA replication. Eukaryotic MCM consists of six gene products, Mcm2–7, which form a heterohexamer. [1] [2] As a critical protein for cell division, MCM is also the target of various checkpoint pathways, such as the S-phase entry and S-phase arrest ...
51428 72935 Ensembl ENSG00000183258 ENSMUSG00000021494 UniProt Q9UJV9 Q91VN6 RefSeq (mRNA) NM_016222 NM_001321732 NM_001321830 NM_134059 RefSeq (protein) NP_001308661 NP_001308759 NP_057306 NP_598820 Location (UCSC) Chr 5: 177.51 – 177.52 Mb Chr 13: 55.68 – 55.68 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Probable ATP-dependent RNA helicase DDX41 is an enzyme that in humans ...
104721 Ensembl ENSG00000079785 ENSMUSG00000037149 UniProt Q92499 Q91VR5 RefSeq (mRNA) NM_004939 NM_134040 RefSeq (protein) NP_004930 NP_598801 Location (UCSC) Chr 2: 15.59 – 15.63 Mb Chr 12: 13.27 – 13.3 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse ATP-dependent RNA helicase DDX1 is an enzyme that in humans is encoded by the DDX1 gene. Function DEAD box proteins, characterized ...
DEAD box proteins are putative RNA helicases characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD). They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution ...
Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, [6] and cellular growth and division. This gene encodes a DEAD box protein, which is an RNA-dependent ATPase, and also a proliferation-associated nuclear antigen, specifically reacting with the simian virus 40 tumor ...