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Increase in systemic exposure is proportional over the dose range of 50–400 mg. No time-dependent change in kinetics was observed through 12 weeks of dosing. Apparent steady state for armodafinil was reached within 7 days of dosing. At steady state, the systemic exposure for armodafinil is 1.8 times the exposure observed after a single dose.
[3] [2] [4] The modafinil analogues are of interest in the potential treatment of a condition involving the misuse of stimulant drugs (psychostimulant use disorder or PSUD), as drugs that help increase motivation (pro-motivational agents) to treat motivational disorders, [4] [5] [6] and for treatment of neurodegenerative diseases such as ...
Modafinil, sold under the brand name Provigil among others, is a central nervous system (CNS) stimulant and eugeroic (wakefulness promoter) medication used primarily to treat narcolepsy, [3] [8] [15] a sleep disorder characterized by excessive daytime sleepiness and sudden sleep attacks. [16]
A new year can mean many new, exciting things. But it also means that tax season is just around the corner. Soon Americans will have to do the yearly task of filing their tax returns for the ...
[1] [8] [9] [10] Eugeroics, in the sense of modafinil-type wakefulness promoting agents, include modafinil itself, armodafinil , and adrafinil , among others. [ 9 ] They are medically indicated for the treatment of certain sleep disorders , including excessive daytime sleepiness (EDS) in narcolepsy or obstructive sleep apnea (OSA).
RIVERHEAD, N.Y. - Accused Gilgo Beach serial killer Rex Heuermann has been charged with a seventh murder. Heuermann was charged with killing Valerie Mack, a 24-year-old from New Jersey who had ...
Lawmakers unveiled a stop-gap spending bill on Tuesday night to prevent a shutdown that funds the government through March 14 and includes $100 billion in disaster relief and other key provisions.
The fifth edition was published in 1979. [6] The sixth and seventh editions were edited by Clarence M. Fraser. [7] The eighth edition, edited by Susan Aeillo, was published in 1988 with contributions from 317 authors. [8] A review in the Canadian Veterinary Journal declared it to be an 'excellent veterinary handbook'. [8]