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The first protease inhibitor approved by the U.S. Food and Drug Administration (FDA). Ritonavir: Norvir: AbbVie: U.S. patent 5,541,206: March 1, 1996: AbbVie was part of Abbott Laboratories when patent was granted. As well as being a protease inhibitor in its own right, ritonavir inhibits the breakdown of other protease inhibitors.
Common side effects include nausea, vomiting, diarrhea, and feeling tired. [4] More serious side effects include problems with QT prolongation, heart block, high blood lipids, and liver problems. [4] It appears to be safe in pregnancy. [4] It is in the protease inhibitor class and works by blocking the HIV protease. [4]
Nelfinavir belongs to the class of drugs known as protease inhibitors (PIs) and like other PIs is almost always used in combination with other antiretroviral drugs. Nelfinavir is an orally bioavailable human immunodeficiency virus HIV-1 protease inhibitor (K i = 2 nM) and is widely prescribed in combination with HIV reverse transcriptase ...
The drug binds to and inhibits CYP3A4, so a low dose can be used to enhance other protease inhibitors. This discovery drastically reduced the adverse effects and improved the efficacy of protease inhibitors and HAART. [35] [36]. However, because of the general role of CYP3A4 in xenobiotic metabolism, dosing with ritonavir also affects the ...
Side effects from the pill, part of Roche's $2.7 billion acquisition of Carmot in December, were mostly gastrointestinal (GI), like those associated with similar drugs.
Nirmatrelvir is a SARS-CoV-2 main protease (M pro, 3CL pro, nsp5 protease) inhibitor while ritonavir is an HIV-1 protease inhibitor and strong CYP3A inhibitor. [ 10 ] [ 19 ] Nirmatrelvir is the main active agent in the formulation, while ritonavir, which inhibits HIV-1 protease , is a strong CYP3A inhibitor : it inhibits the metabolization of ...
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