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The dermis is composed of three major types of cells: [3] fibroblasts, macrophages, and mast cells.. Apart from these cells, the dermis is also composed of matrix components such as collagen (which provides strength), elastin (which provides elasticity), and extrafibrillar matrix, an extracellular gel-like substance primarily composed of glycosaminoglycans (most notably hyaluronan ...
Keratinocytes form tight junctions with the nerves of the skin and hold the Langerhans cells and intra-dermal lymphocytes in position within the epidermis. Keratinocytes also modulate the immune system : apart from the above-mentioned antimicrobial peptides and chemokines they are also potent producers of anti-inflammatory mediators such as IL ...
The epidermis is the outermost of the three layers that comprise the skin, the inner layers being the dermis and hypodermis. [1] The epidermal layer provides a barrier to infection from environmental pathogens [2] and regulates the amount of water released from the body into the atmosphere through transepidermal water loss.
Stratum basale labeled near bottom. The stratum basale (basal layer, sometimes referred to as stratum germinativum) is the deepest layer of the five layers of the epidermis, the external covering of skin in mammals. The stratum basale is a single layer of columnar or cuboidal basal cells.
Human skin pigmentation varies substantially between populations; this has led to the classification of people(s) on the basis of skin colour. [3] In terms of surface area, the skin is the second largest organ in the human body (the inside of the small intestine is 15 to 20 times larger).
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The word ectoderm comes from the Greek ektos meaning "outside", and derma meaning "skin". [2] Generally speaking, the ectoderm differentiates to form epithelial and neural tissues (spinal cord, nerves and brain). This includes the skin, linings of the mouth, anus, nostrils, sweat glands, hair and nails, [3] and tooth enamel. Other types of ...
The stratum lucidum (Latin, 'clear layer') is a thin, clear layer of dead skin cells in the epidermis named for its translucent appearance under a microscope. It is readily visible by light microscopy only in areas of thick skin , which are found on the palms of the hands and the soles of the feet.