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Inclusion bodies are aggregates of specific types of protein found in neurons, and a number of tissue cells including red blood cells, bacteria, viruses, and plants. Inclusion bodies of aggregations of multiple proteins are also found in muscle cells affected by inclusion body myositis and hereditary inclusion body myopathy. [1]
The reticulate body substantially modifies the inclusion, making it a more hospitable environment for rapid replication of the bacteria, which occurs over the following 30 to 72 hours. [17] The massive number of intracellular bacteria then transition back to resistant elementary bodies before causing the cell to rupture and being released into ...
Chlamydia may be found in the form of an elementary body and a reticulate body. The elementary body is the nonreplicating infectious particle that is released when infected cells rupture. It is responsible for the bacteria's ability to spread from person to person and is analogous to a spore. The elementary body may be 0.25 to 0.30 μm in diameter.
Most intracellular Chlamydiota are located in an inclusion body or vacuole. Outside cells, they survive only as an extracellular infectious form. These Chlamydiota can grow only where their host cells grow, and develop according to a characteristic biphasic developmental cycle.
Histologically, molluscum contagiosum is characterized by molluscum bodies (also known as Henderson-Patterson bodies) in the epidermis, above the stratum basale, which consist of cells with abundant large granular eosinophilic cytoplasmic inclusion bodies (accumulated virions) and a small nucleus that has been pushed to the periphery. [19] [20]
Chlamydia pneumoniae [1] is a species of Chlamydia, an obligate intracellular bacterium [2] that infects humans and is a major cause of pneumonia.It was known as the Taiwan acute respiratory agent (TWAR) from the names of the two original isolates – Taiwan (TW-183) and an acute respiratory isolate designated AR-39. [3]
Examples of inclusions are glycogen granules in the liver and muscle cells, lipid droplets in fat cells, pigment granules in certain cells of skin and hair, and crystals of various types. [3] Cytoplasmic inclusions are an example of a biomolecular condensate arising by liquid-solid, liquid-gel or liquid-liquid phase separation.
Type-A inclusion bodies are found only in certain poxviruses like cowpox. [3] The Guarnieri bodies are found in all poxvirus infections and their presence is diagnostic. [ 4 ] The diagnosis of an orthopoxvirus infection can also be made rapidly by electron microscopic examination of pustular fluid or scabs.