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This accumulation results in therapeutic levels of terbinafine even after 80 days following one week treatment of 250 mg/day. Different dosing schedules have been proposed such as 500 mg/day for one week or 250 mg/day for two weeks each followed by a drug-free period of two or three weeks, totaling 3 months of treatment including the drug-free ...
At the same time, there is research suggesting that topical terbinafine — though at a hefty concentration of 10%, not the lower 1% found in Lamisil — can effectively kill toenail fungus with a ...
As of 2015 in the US, the 1% topical cream is generic OTC for about $15/oz. But the 250mg oral tablets require a prescription and retail for well over $1 per tablet -- yet are commonly covered by various discount programs that can bring the cost down to about $10 per month (30 tablets).
On September 28, 2007, the U.S. Food and Drug Administration stated that Lamisil (Terbinafine hydrochloride, by Novartis AG) is a new treatment approved for use by children aged 4 years and older. The antifungal granules can be sprinkled on a child's food to treat the infection. [16]
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Archaeologists used radiocarbon dating to date one mass grave to between the late 1400s and early 1600s, and found shards of pottery and coins dating from the later end of that range at the site.