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Use of barrier membranes to direct bone regeneration was first described in the context of orthopaedic research 1959. [2] The theoretical principles basic to guided tissue regeneration were developed by Melcher in 1976, who outlined the necessity of excluding unwanted cell lines from healing sites to allow growth of desired tissues. [3]
Guided tissue regeneration (GTR) using PTFE membranes is favoured by some practitioners, despite its cost and complexity: "GTR has a greater effect on probing measures of periodontal treatment than open flap debridement, including improved attachment gain, reduced pocket depth, less increase in gingival recession and more gain in hard tissue ...
A successful tissue regeneration relies on an appropriate source of stem progenitor cells, growth factors and scaffolds to control the development of the specific tissue. [19] The first component for tissue engineering is an appropriate source of progenitor/stem cells by using cells which are able to differentiate into the desired tissue component.
It is still unclear exactly how EMD participates in the regeneration process. [5] But it has been demonstrated that EMD serves to promote periodontal ligament fibroblast proliferation and growth and inhibit epithelial cell proliferation and growth; [3] this is a key feature in EMD-promoted periodontal tissue regeneration, because the faster-growing epithelium will ordinarily compete very ...
PETTI Gustavo From Cagliari, Italy has been the first one to have had: "A new attachment: guided tissue regeneration using an amniotic membrane and fibrin glue" Publication: Petti G. (1989) “La rigenerazione parodontale guidata con membrana amniotica e colla di fibrina. (Guided periodontal regeneration with an amniotic membrane and fibrin glue).
The use of lasers in treating periodontal disease has been seen by some dental professionals as controversial. [6] The American Academy of Periodontology stated in 1999 that it was "not aware of any randomized blinded controlled longitudinal clinical trials, cohort or longitudinal studies, or case-controlled studies indicating that 'laser excisional new attachment procedure (or Laser ENAP)' or ...