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Lactose intolerance is distinct from milk allergy, an immune response to cow's milk proteins. They may be distinguished in diagnosis by giving lactose-free milk, producing no symptoms in the case of lactose intolerance, but the same reaction as to normal milk in the presence of a milk allergy. A person can have both conditions.
This is an autosomal recessive disorder and infants that can’t break down lactose have trouble with breastmilk, and develop diarrhea starting from birth. Sometimes, even those with lactase-persistence can develop temporary lactose intolerance as a result of infection or inflammation in the small intestine.
Lactose can not be absorbed by the intestine and needs to be split in the small intestine into galactose and glucose by the enzyme called lactase; unabsorbed lactose can cause abdominal pain, bloating, diarrhea, gas, and nausea. [citation needed] In most mammals, production of lactase diminishes after infants are weaned from maternal milk.
Humans are born with high levels of lactase expression. In most of the world's population, lactase transcription is down-regulated after weaning, resulting in diminished lactase expression in the small intestine, [22] which causes the common symptoms of adult-type hypolactasia, or lactose intolerance. [23]
Not to be confused with lactose intolerance. [27] Allergy to cow's milk is the most common food allergy in infants and young children [11] but most outgrow the allergy in early childhood. Introducing baked cow's milk to allergic patients is associated with accelerated resolution of milk allergy. [28]
Fructose malabsorption and lactose intolerance may produce IBS symptoms through the same mechanism, but unlike other FODMAPs, poor absorption of fructose is found in only a minority of people. Lactose intolerance is found in most adults, except for specific geographic populations, notably those of European descent. [20]
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It is an autosomal recessive metabolic disorder that can cause liver disease and death if untreated. Treatment of galactosemia is most successful if initiated early and includes dietary restriction of lactose intake. Because early intervention is key, galactosemia is included in newborn screening programs in many areas.