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Naltrexone potentiates psychotomimetic effects of a low dose of ketamine, [88] while lamotrigine [38] and nimodipine [39] decrease them. Clonidine reduces the increase of salivation, heart rate, and blood pressure during ketamine anesthesia and decreases the incidence of nightmares.
When used for procedural sedation these are started at low dose then titrated to reach the desired effect. [1] Fentanyl is a synthetic opioid, 75-125 times stronger than morphine, [3] that acts by activating opioid receptors in the nervous system. Its effects begin in 2–3 minutes, and last 30–60 minutes.
The use of ketamine as an antidepressant has mainly been studied for the treatment of treatment-resistant depression(TRD). Single-dose use has been found to have noticeable and rapid anti-depressive effects that tend to last up to a week, accompanied by acute side-effects that resolve spontaneously. [22]
"Ketamine can induce a state of sedation (feeling calm and relaxed), immobility, relief from pain, and amnesia (no memory of events while under the influence of the drug) and is abused for the ...
Using the two drugs together poses a "major" risk and can increase side effects like "dizziness, drowsiness, confusion, difficulty concentrating, excessive sedation, and respiratory depression ...
NMDA receptor antagonists induce a state called dissociative anesthesia, marked by catalepsy, amnesia, and analgesia. [1] Ketamine is a favored anesthetic for emergency patients with unknown medical history and in the treatment of burn victims because it depresses breathing and circulation less than other anesthetics.
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