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Splenic marginal zone lymphoma (SMZL) is a type of marginal zone lymphoma, a cancer made up of B-cells that replace the normal architecture of the white pulp of the spleen. The neoplastic cells are both small lymphocytes and larger, transformed lymphoblasts , and they invade the mantle zone of splenic follicles and erode the marginal zone ...
Histology of a normal lymphoid follicle, with marginal zone annotated at bottom.. Numerous factors appear to be involved in the development of EMZL. In a small number of cases where there is a family history of a blood cancer particularly leukemia, or a number of autoimmune diseases such as Sjögren syndrome and lupus erythematosus, there is seen to be an increased frequency.
Intravascular lymphomas (IVL) are rare cancers in which malignant lymphocytes proliferate and accumulate within blood vessels. Almost all other types of lymphoma involve the proliferation and accumulation of malignant lymphocytes in lymph nodes, other parts of the lymphatic system (e.g. the spleen), and various non-lymphatic organs (e.g. bone marrow and liver) but not in blood vessels.
Lymphoma is a group of blood and lymph tumors that develop from lymphocytes (a type of white blood cell). [7] The name typically refers to just the cancerous versions rather than all such tumours. [7] Signs and symptoms may include enlarged lymph nodes, fever, drenching sweats, unintended weight loss, itching, and constantly feeling tired.
Non-Hodgkin’s lymphoma (NHL) is one of the most common forms of blood cancer.1 The American Cancer Society estimates that about 81,560 people in the U.S. will be diagnosed with NHL and about ...
Most commonly, patients have no symptoms at first. [12] In a small number of cases, patients with CLL may present with enlarged lymph nodes, partially in areas around the neck, armpit, or groin. [12] If CLL-type cells are only found in the lymph nodes, a diagnosis of small lymphocytic lymphoma (SLL) is made. [20]