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Mepolizumab. Mepolizumab, sold under the brand name Nucala by GlaxoSmithKline, is a humanized monoclonal antibody used for the treatment of severe eosinophilic asthma, eosinophilic granulomatosis with polyangiitis, and hypereosinophilic syndrome (HES). [ 5 ] It recognizes and blocks interleukin-5 (IL-5), a signalling protein of the immune system.
September 6, 2024 at 2:17 AM. (Reuters) -British drugmaker GSK said on Friday that its asthma drug, Nucala, met the main goal of a late-stage study in treating patients with chronic obstructive ...
May 20, 2024 at 11:29 PM. (Reuters) -GSK's experimental drug met its primary goal of reducing asthma attacks in a late-stage trial, marking a bright spot for a treatment that the British drugmaker ...
Treatment. corticosteroids. Eosinophilic bronchitis (EB) is a type of airway inflammation due to excessive mast cell recruitment and activation in the superficial airways as opposed to the smooth muscles of the airways as seen in asthma. [1][2] It often results in a chronic cough. [1] Lung function tests are usually normal. [1]
Anti-asthmatic agents. Anti-asthmatic agents refer to drugs that can aid in airway smooth muscle dilation to allow normal breathing during an asthma attack or reduce inflammation on the airway to decrease airway resistance for asthmatic patients, or both. The goal of asthmatic agents is to reduce asthma exacerbation frequencies and related ...
Eosinophil cationic protein (ECP) also known as ribonuclease 3 is a basic protein located in the eosinophil primary matrix. [4] In humans, the eosinophil cationic protein is encoded by the RNASE3 gene. [5] ECP is released during degranulation of eosinophils. This protein is related to inflammation and asthma because in these cases, there are ...
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