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Lupus anticoagulant. Lupus anticoagulant is an immunoglobulin [1] that binds to phospholipids and proteins associated with the cell membrane. Its name is a partial misnomer, as it is actually a prothrombotic antibody in vivo. The name derives from their properties in vitro, as these antibodies increase coagulation times in laboratory tests such ...
Rheumatology, immunology. Lupus erythematosus is a collection of autoimmune diseases in which the human immune system becomes hyperactive and attacks healthy tissues. [1] Symptoms of these diseases can affect many different body systems, including joints, skin, kidneys, blood cells, heart, and lungs. The most common and most severe form is ...
SS-A and SS-B confer a specific risk for heart conduction block in neonatal lupus. [93] Other tests routinely performed in suspected SLE are complement system levels (low levels suggest consumption by the immune system), electrolytes and kidney function (disturbed if the kidney is involved), liver enzymes, and complete blood count. [citation ...
Libman–Sacks endocarditis involves formation of cardiac lesions that may take the form of vegetations or thickening of the valvular leaflets. [4][2] The vegetations are small and formed from strands of fibrin, neutrophils, lymphocytes, and histiocytes. [5] Vegetations are most often small-to-moderate in size (up to 10 mm), [4] but may ...
The Centers for Disease Control and Prevention estimates that more than 200,000 people in the U.S. have lupus, though the Lupus Foundation of America puts the total much higher: roughly 1.5 ...
Anti-Ro antibodies are also found less frequently in other disorders including autoimmune liver diseases, coeliac disease, autoimmune rheumatic diseases, cardiac neonatal lupus erythematosus and polymyositis. [19] [20] During pregnancy, anti-Ro antibodies can cross the placenta and cause heart block [21] [22] and neonatal lupus in babies. [23]
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