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Different degrees of improvement are referred to as ACR20, ACR50, ACR70. ACR20 was initially proposed with ACR scoring, measuring a 20% improvement on a scale of 28 intervals. ACR50 and ACR70 were later proposed, corresponding to 50% and 70% improvements. [2] The Rheumatoid Arthritis Severity Scale (RASS) is based on sections of the ACR scoring ...
ACR20 was achieved by 71% versus 36%, and DAS28CRP<2.6 by 29% versus 6%. Upadacitinib was superior to adalimumab for ACR50, DAS28CRP≤3.2, ΔPain and ΔHAQDI. At week 26, more participants on upadacitinib vs placebo or adalimumab achieved low disease activity or remission (p≤0.001).
[8] [5] [129] A combined approach with methotrexate and biologics improves ACR50, HAQ scores and RA remission rates. [ 130 ] [ 58 ] This benefit from the combination of methotrexate with biologics occurs both when this combination is the initial treatment and when drugs are prescribed in a sequential or step-up manner. [ 58 ]
The Toyota Previa, also known as the Toyota Estima (Japanese: トヨタ・エスティマ, Hepburn: Toyota Esutima) in Japan, and Toyota Tarago in Australia, is a minivan that was produced by Toyota from 1990 until October 2019 across three generations.
A hybrid version was also added to the lineup in MY 2003, featuring a 2.4-litre 2AZ-FXE Atkinson cycle petrol engine with a power output of 133 PS (98 kW; 131 hp) and 190 N⋅m (140 lb⋅ft) of torque which has been developed specifically for use in Toyota's Hybrid Synergy Drive technology and features a high-expansion ratio cycle that raises efficiency and reduces friction; however, this led ...
The 2AZ-FE engine in the 2007-2009 Camry and 2006-2009 Rav4 may burn excessive oil and is involved in this lawsuit. [1] Other engines are also affected. [2] If this Toyota engine is burning more than 1 US quart (946 ml) of oil in 1,200 miles (1,931 km), has less than 150,000 miles (241,402 km), is less than 10 years old, and is located in the U.S., Toyota service will perform a free oil ...
The XR100R was first introduced with the R designation in 1985, four years after the XR100 was brought to market. A major difference between the two was a major rear suspension upgrade to a more race-like single coil-over design (monoshock) and a new swingarm over the traditional dual real coil-over systems on the XR100.