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2. Antisense therapy - Wikipedia

   en.wikipedia.org/wiki/Antisense_therapy

   Antisense therapy is a form of treatment that uses antisense oligonucleotides (ASOs) to target messenger RNA (mRNA). ASOs are capable of altering mRNA expression through a variety of mechanisms, including ribonuclease H mediated decay of the pre-mRNA, direct steric blockage, and exon content modulation through splicing site binding on pre-mRNA. [1]

3. Optimer ligand - Wikipedia

   en.wikipedia.org/wiki/Optimer_Ligand

   Optimer therapeutics are being developed in partnership with Cancer Research UK that can selectively target a key gene fault for the treatment of Chronic Myelomonocytic Leukaemia (CMML) and other myeloid malignancies. [16] Optimer conjugate therapies are being developed in partnership with AstraZeneca [22] and PinotBio. [14]

4. Oblimersen - Wikipedia

   en.wikipedia.org/wiki/Oblimersen

   Oblimersen (INN, trade name Genasense; also known as Augmerosen and bcl-2 antisense oligodeoxynucleotide G3139) is an antisense oligodeoxyribonucleotide being studied as a possible treatment for several types of cancer, including chronic lymphocytic leukemia, B-cell lymphoma, and breast cancer.

5. Oligonucleotide synthesis - Wikipedia

   en.wikipedia.org/wiki/Oligonucleotide_synthesis

   The newly formed tricoordinated phosphite triester linkage is not natural and is of limited stability under the conditions of oligonucleotide synthesis. The treatment of the support-bound material with iodine and water in the presence of a weak base (pyridine, lutidine, or collidine) oxidizes the phosphite triester into a tetracoordinated ...

6. Gapmer - Wikipedia

   en.wikipedia.org/wiki/Gapmer

   Tegsedi, developed and marketed by Ionis Pharmaceuticals, was approved by the FDA in October 2018 for the treatment of hereditary transthyretin amyloidosis (hATTR). [10] The chemical structure is a 20-mer oligonucleotide with PS backbone modifications and 2'-MOE ribose substitutions. [4]

7. Oligonucleotide - Wikipedia

   en.wikipedia.org/wiki/Oligonucleotide

   Oligonucleotides are short DNA or RNA molecules, oligomers, that have a wide range of applications in genetic testing, research, and forensics.Commonly made in the laboratory by solid-phase chemical synthesis, [1] these small fragments of nucleic acids can be manufactured as single-stranded molecules with any user-specified sequence, and so are vital for artificial gene synthesis, polymerase ...