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The Mercer protocol is a common regimen for antibiotic prophylaxis in the context of preterm premature rupture of membranes (PPROM) during pregnancy, when immediate delivery is contraindicated due to known or suspected fetal lung immaturity.
But, "Intrapartum antibiotic prophylaxis should be offered if GBS is detected on a vaginal swab in the current pregnancy." [citation needed] The 2003 RCOG guideline was reviewed in September 2017 without substantial changes. [39]
While antibiotics can get rid of bacterial vaginosis in pregnancy, this does not appear to change the risk of preterm birth. [115] It has been suggested that chronic chorioamnionitis is not sufficiently treated by antibiotics alone (and therefore they cannot ameliorate the need for preterm delivery in this condition).
[14] [12] However, all NSAIDs showed association with structural cardiac defects with usage during the early weeks of pregnancy. When ibuprofen and naproxen are used within the third trimester, there is a significant increase in the risk of premature closure of the ductus arteriosus with primary pulmonary hypertension in the newborn. [ 12 ]
Trimethoprim (TMP) is an antibiotic used mainly in the treatment of bladder infections. [1] Other uses include for middle ear infections and travelers' diarrhea. [1] With sulfamethoxazole or dapsone it may be used for Pneumocystis pneumonia in people with HIV/AIDS. [1] [2] It is taken orally (swallowed by mouth). [1]
Chorioamnionitis is caught early by looking at signs and symptoms such as fever, abdominal pain, or abnormal vaginal excretion. [8] Administration of antibiotics if the amniotic sac bursts prematurely can prevent chorioamnionitis occurrence. [9]
Early onset sepsis can occur in the first week of life. It usually is apparent on the first day after birth. This type of infection is usually acquired before the birth of the infant. Premature rupture of membranes and other obstetrical complications can add to the risk of early-onset sepsis. If the amniotic membrane has been ruptured greater ...
Antibiotics have been used to prevent and treat these infections—however, the misuse of antibiotics is a serious problem for global health. [2] It is recommended that guidelines be followed that outline when it is appropriate to give antibiotics and which antibiotics are most effective. [2]