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Wolkowitz et al. (2001) presented a 10-year-old male patient, with no prior psychiatric history, who showed significant declines in academic performance that began during a 5-week course of glucocorticoid treatment for acute asthma flare. [1] The medications included prednisone, and methylprednisolone, plus albuterol, beclomethasone ...
Mucokinetics: increase mucociliary transport (clearance) and transportability of mucus by cough [2] Mucoregulators : suppress underlying mechanisms of mucus hypersecretion [ 2 ] Alternatively, attacking the affinity between secretions and the biological surfaces is another avenue, which is used by abhesives and surfactants .
Prednisone is a synthetic glucocorticoid used for its anti-inflammatory and immunosuppressive properties. [36] [37] Prednisone is a prodrug; it is metabolised in the liver by 11-β-HSD to prednisolone, the active drug. Prednisone has no substantial biological effects until converted via hepatic metabolism to prednisolone. [38]
[49] [50] When nebulized, budesonide has an bioavailability of 6% and reaches C max within 1–3 hours. [50] [49] When formulated as a rectal foam, budesonide has an bioavailability of 3% to 27% and reaches C max around 1.5 hours. [51] The plasma protein binding of budesonide is around 85-90%, with an apparent volume of distribution of 2.2-3.9L/kg.
[2] [4] [5] Non-asthmatic eosinophilic bronchitis is different from asthma in that it does not have airflow obstruction or airway hyperresponsiveness. [6] Along with eosinophils, the number of mast cells , another type of white blood cell, is also significantly increased in the bronchial wash fluid of eosinophilic bronchitis patients compared ...
Prednisolone is a synthetic pregnane corticosteroid closely related to its cognate prednisone, having identical structure save for two fewer hydrogens near C 11. It is also known as δ 1 -cortisol , δ 1 -hydrocortisone , 1,2-dehydrocortisol , or 1,2-dehydrohydrocortisone , as well as 11β,17α,21-trihydroxypregna-1,4-diene-3,20-dione .
A phlegmon is a localized area of acute inflammation of the soft tissues. It is a descriptive term which may be used for inflammation related to a bacterial infection or non-infectious causes (e.g. pancreatitis).
[1] Some common naturally occurring steroid hormones are cortisol (C 21 H 30 O 5), corticosterone (C 21 H 30 O 4), cortisone (C 21 H 28 O 5) and aldosterone (C 21 H 28 O 5) (cortisone and aldosterone are isomers). The main corticosteroids produced by the adrenal cortex are cortisol and aldosterone. [1]