Ads
related to: carboplatin side effects in women elderly patients
Search results
Results From The WOW.Com Content Network
Carboplatin, sold under the brand name Paraplatin among others, is a chemotherapy medication used to treat a number of forms of cancer. [3] This includes ovarian cancer, lung cancer, head and neck cancer, brain cancer, and neuroblastoma. [3] It is used by injection into a vein. [3] Side effects generally occur. [3]
Addition of platinum-based chemotherapy drugs to chemoradiation in women with early cervical cancer seems to improve survival and reduce risk of recurrence. [2] In total, these drugs can cause a combination of more than 40 specific side effects which include neurotoxicity, which is manifested by peripheral neuropathies including polyneuropathy. [3]
The incidence of debilitating grades of diarrhea was reduced from 18% in the BSA-dosed group to 4% in the dose-adjusted group and serious hematologic side effects were eliminated. [23] Because of the reduced toxicity, dose-adjusted patients were able to be treated for longer periods of time. [23]
Carboplatin may be associated with a higher risk of thrombocytopenia. Cisplatin may cause more nausea or vomiting when compared to carboplatin treatment. [46] PD‐L1 inhibitors are more effective and lead to longer survival with fewer side effects compared to platinum-based chemotherapy. [48]
Carboplatin tends to fare better than cisplatin for side effects and use in outpatient setting in randomized clinical trials. [31] Paclitaxel is a particularly effective add-on for late stage ovarian cancer. [31] Some studies suggest that intraperitoneal chemotherapy may be advantageous over an intravenous route. [31]
Some of the hazards and side effects that were formerly linked to larger dosages of chemotherapy medications have been lessened thanks to these improvements. Severe suppression of the bone marrow , heightened vulnerability to infections , gastrointestinal toxicity , and more systemic problems were among the possible side effects.