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Polysorbate 80 is a surfactant and solubilizer used in a variety of oral and topical pharmaceutical products. Polysorbate 80 is also an excipient that is used to stabilize aqueous formulations of medications for parenteral administration, and used as an emulsifier in the making of the antiarrhythmic amiodarone . [ 9 ]
Polysorbate 20, a compound used as a food additive in some pudding mixes to prevent scorching during preparation. Polysorbates are a class of emulsifiers used in some pharmaceuticals and food preparation. They are commonly used in oral and topical pharmaceutical dosage forms.
It was encapsulated in polysorbate 80 coated nanoparticles and intravenously injected. [5] This was a huge breakthrough in the nanoparticle drug delivery field, and it helped advance research and development toward clinical trials of nanoparticle delivery systems.
Examples synthesized on an industrial scale include octyl phenol ethoxylate, polysorbate 80 and poloxamers. Ethoxylation is commonly practiced, albeit on a much smaller scale, in the biotechnology and pharmaceutical industries to increase water solubility and, in the case of pharmaceuticals, circulatory half-life of non-polar organic compounds.
The chemical structure shown for Polysorbate 80 appears to be incorrect. Polysorbate 80 is made by polymerization of 20 equivalents of ethylene oxide with sorbitan monooleate [1]. The method of synthesis is summarized in Chapter 2 of Food Emulsifiers and Their Applications: Hasenhuettl, Gerard L., Hartel, Richard W. (Eds.) [2]. Aside from the ...
Docetaxel is a white powder and is the active ingredient available in 20 mg and 80 mg Taxotere single-dose vials of concentrated anhydrous docetaxel in polysorbate 80. [ 16 ] [ 17 ] The solution is a clear brown-yellow containing 40 mg docetaxel and 1040 mg polysorbate 80 per mL.
Sorbitan monooleate (commercially: Span® 80; Croda International PLC) is a nonionic surfactant and emulsifier widely used in various industries, including food, pharmaceuticals, and cosmetics. It is a sorbitan ester produced by the esterification of sorbitan with oleic acid, resulting in a light yellow, viscous liquid that is insoluble in ...
Psychology Today content and its therapist directory are found in 20 countries worldwide. [3] Psychology Today's therapist directory is the most widely used [4] and allows users to sort therapists by location, insurance, types of therapy, price, and other characteristics. It also has a Spanish-language website.