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The indometacin property of reducing cerebral blood flow is useful in treating raised intracranial pressure. A case report has shown that an intravenous bolus dose of indometacin given with 2 hours of continuous infusion is able to reduce intracranial pressure by 37% in 10 to 15 minutes and increases cerebral perfusion pressure by 30% at the ...
Prostaglandin inhibitors are drugs that inhibit the synthesis of prostaglandin in human body. [1] There are various types of prostaglandins responsible for different physiological reactions such as maintaining the blood flow in stomach and kidney, regulating the contraction of involuntary muscles and blood vessels, and act as a mediator of inflammation and pain.
Pain and anti-inflammatory drugs like Indomethacin, nonsteroidal anti-inflammatory drugs and piroxicam would retain water in the systemic circulation, raising the blood pressure. [16] Other types of medications like antidepressant, hormone and caffeine would also increase blood pressure.
Bradycardia; Hypertension (high blood pressure); Allergic reactions (e.g. dyspnoea (shortness of breath), bronchospasm, wheezing, angioneurotic oedema) Anaphylaxis; Changes in appetite
Indomethacin in a study by Blanchard et al. 2015 was shown to increase serum potassium levels, and decrease renin concentration. Adverse effects of indomethacin include a decrease in the glomerular filtration rate, and gastrointestinal disturbances. [24] Therefore, these drugs should also be used only with caution in Gitelman syndrome. [21]
Dehydration can sometimes cause blood pressure to drop. “You expect that if someone gets dehydrated, their blood pressure will go down,” says Evan Appelbaum, MD, cardiologist, Men’s Health ...