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Mallory–Weiss syndrome is a condition where high intra-abdominal pressures causes laceration and bleeding of the mucosa called Mallory-Weiss tears. [1] Additionally, Mallory–Weiss syndrome is one of the most common causes of acute upper gastrointestinal bleeding, counting of around 1-15% of all cases in adults and less than 5% in children.
Asclepiades of Ephesus was an ancient Roman man who possibly died of a digestive hemorrhage due to high amounts of alcohol intake, possibly because a doctor prescribed alcohol as medication. Alternatively, binge-drinking may have induced Mallory-Weiss Syndrome, which is bleeding from the mucosa in the stomach and esophagus. [6]
In 1929, Mallory and Soma Weiss, a physician at Harvard, reported on 15 cases of severe, painless hemorrhage caused by a tear in the mucosa of the esophagus or gastroesophageal junction preceded by vomiting in alcoholic patients. [3] They reported a further six cases in 1932. [4] This syndrome has become known as Mallory–Weiss syndrome.
Mallory-Weiss tear; Gastric causes: Gastric ulcer; Gastric cancer; Gastritis; Gastric varices; Gastric antral vascular ectasia; Dieulafoy's lesions; Duodenal causes: Duodenal ulcer; Vascular malformation, including aorto-enteric fistulae. Fistulae are usually secondary to prior vascular surgery and usually occur at the proximal anastomosis at ...
[3] [4] A related condition is Mallory-Weiss syndrome which is only a mucosal tear. A common site of iatrogenic perforation is the cervical esophagus just above the upper sphincter, whereas spontaneous rupture as seen in Boerhaave syndrome perforation commonly occurs in the lower third of the esophagus. [5]
These cells are particularly attracted to hepatocytes with Mallory bodies. [6] If chronic liver disease is also present: Fibrosis; Cirrhosis – a progressive and permanent type of fibrotic degeneration of liver tissue. Pathogenesis alcoholic liver injury Alcohol related liver disease
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Chronic diseases of malabsorption may affect the small intestine, including the autoimmune coeliac disease, infective tropical sprue, and congenital or surgical short bowel syndrome. Other rarer diseases affecting the small intestine include Curling's ulcer, blind loop syndrome, Milroy disease and Whipple's disease.