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  2. Hyperuricemia - Wikipedia

    en.wikipedia.org/wiki/Hyperuricemia

    Hyperuricaemia or hyperuricemia is an abnormally high level of uric acid in the blood. In the pH conditions of body fluid , uric acid exists largely as urate, the ion form. [ 1 ] [ 2 ] Serum uric acid concentrations greater than 6 mg/dL for females, 7 mg/dL for males, and 5.5 mg/dL for youth (under 18 years old) are defined as hyperuricemia. [ 3 ]

  3. Rasburicase - Wikipedia

    en.wikipedia.org/wiki/Rasburicase

    Urate oxidase is known to be present in many mammals but does not naturally occur in humans. [3] Rasburicase is produced by a genetically modified Saccharomyces cerevisiae strain. The complementary DNA (cDNA) coding for rasburicase was cloned from a strain of Aspergillus flavus. [3] Rasburicase is a tetrameric protein with identical subunits.

  4. Probenecid - Wikipedia

    en.wikipedia.org/wiki/Probenecid

    Probenecid is primarily used to treat gout and hyperuricemia. Probenecid is sometimes used to increase the concentration of some antibiotics and to protect the kidneys when given with cidofovir. Specifically, a small amount of evidence supports the use of intravenous cefazolin once rather than three times a day when it is combined with ...

  5. Gout - Wikipedia

    en.wikipedia.org/wiki/Gout

    Hyperuricemia is a classic feature of gout, but nearly half of the time gout occurs without hyperuricemia and most people with raised uric acid levels never develop gout. [ 10 ] [ 52 ] Thus, the diagnostic utility of measuring uric acid levels is limited. [ 10 ]

  6. Uric acid - Wikipedia

    en.wikipedia.org/wiki/Uric_acid

    A 2011 survey in the United States indicated that 3.9% of the population had gout, whereas 21.4% had hyperuricemia without having symptoms. [ 43 ] Excess blood uric acid (serum urate) can induce gout , [ 44 ] a painful condition resulting from needle-like crystals of uric acid termed monosodium urate crystals [ 45 ] precipitating in joints ...

  7. Hyperuricosuria - Wikipedia

    en.wikipedia.org/wiki/Hyperuricosuria

    Medications that may contribute to the cure or amelioration of hyperuricosuria include allopurinol which acts by inhibiting xanthine oxidase and reducing uric acid production. [2] Hyperuricosuria may be a medical sign of: Gout (very common) Kidney stones of uric acid (uric acid nephrolithiasis) Acute uric acid nephropathy; Acute kidney failure

  8. Diuretic - Wikipedia

    en.wikipedia.org/wiki/Diuretic

    There are several categories of diuretics. All diuretics increase the excretion of water from the body, through the kidneys. There exist several classes of diuretic, and each works in a distinct way. Alternatively, an antidiuretic, such as vasopressin (antidiuretic hormone), is an agent or drug which reduces the excretion of water in urine.

  9. Thiazide - Wikipedia

    en.wikipedia.org/wiki/Thiazide

    Thiazide diuretics inhibit this receptor, causing the body to release NaCl and water into the lumen, thereby increasing the amount of urine produced each day. [6] An example of a molecule that is chemically a thiazide but not used as a diuretic is methylchloroisothiazolinone , often found as an antimicrobial in cosmetics.