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Phenylpropanolamine was first synthesized in the early 20th century, in or around 1910. [21] [11] It was patented as a mydriatic in 1913. [21] The pressor effects of phenylpropanolamine were characterized in the late 1920s and the 1930s. [21] Phenylpropanolamine was first introduced for medical use by the 1930s. [23] [11]
The original packaging used the phrase "Ayds Reducing Plan vitamin and mineral Candy"; a later version used the phrase "appetite suppressant candy". The active ingredient was originally benzocaine, [1] presumably to reduce the sense of taste to reduce eating, later changed in the candy (as reported by The New York Times) to phenylpropanolamine. [2]
Beyond adverse effects from the herb itself, "adulteration, inappropriate formulation, or lack of understanding of plant and drug interactions have led to adverse reactions that are sometimes life threatening or lethal." [3]
Plant extract sold as a dietary supplement: Contains ephedrine, an adrenergic agonist: Banned in 2004 for safety reasons 0.9 kilograms (2.0 lb) per month more than placebo [75] Amphetamine salts: Obetrol: Approved 1960, withdrawn 1973; Adderall was later approved for ADHD and narcolepsy and is still used for those purposes Phenylpropanolamine
Dexatrim is an over-the-counter (OTC) dietary supplement meant to assist with weight loss. Dexatrim claims it "gives you the power to lose weight, curb binges, and keep you in control of your diet." Dexatrim claims it "gives you the power to lose weight, curb binges, and keep you in control of your diet."
A drug combination chart designed for harm reduction by TripSit [1] Polysubstance use or multisubstance use is the use of combinations of psychoactive substances with both legal and illegal substances. This page lists polysubstance combinations that are entheogenic, recreational, or off-label indicated use of pharmaceuticals.
This includes supplements which contain a listed chemical, regardless of their dosage form or packaging and regardless of whether the chemical mixture, drug product or dietary supplement is exempt from regulatory controls. For each chemical, its illicit manufacturing use is given in parentheses.
Norephedrine (phenylpropanolamine) is an active metabolite of ephedrine formed via N-demethylation. [ 6 ] [ 10 ] About 8 to 20% of an oral dose of ephedrine is demethylated into norephedrine, about 4 to 13% is oxidatively deaminated into benzoic acid , and a small fraction is converted into 1,2-dihydroxy-1-phenylpropane.