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Androgen replacement therapy (ART), often referred to as testosterone replacement therapy (TRT), is a form of hormone therapy in which androgens, often testosterone, are supplemented or replaced. It typically involves the administration of testosterone through injections, skin creams, patches, gels, pills, or subcutaneous pellets.
It is recommended that individuals with prostate cancer should not use the medication. [9] It can cause harm to the baby if used during pregnancy or breastfeeding. [9] Testosterone is in the androgen family of medications. [9] Testosterone was first isolated in 1935, and approved for medical use in 1939.
LGD-4033 has been assessed in clinical trials at single doses ranging from 0.1 to 22 mg and at repeated doses ranging from 0.1 to 2 mg/day for 3 to 12 weeks. [11] The drug sold via black-market Internet suppliers and used non-medically is often taken at much higher doses than those used in repeated-dose clinical trials (e.g., 5–10 mg/day), with unknown adverse effects and risks.
[48] [51] [52] MSC treatment also appears to improve the control of cerebral blood flow and blood–brain barrier permeability, [53] [54] as well as what is currently thought to be the most important mechanism of MSC treatment after stroke, the activation of endogenous neuroprotection and neurorestoration pathways by the release of cytokines ...
Drug titration is the process of adjusting the dose of a medication for the maximum benefit without adverse effects. [ 1 ] When a drug has a narrow therapeutic index , titration is especially important, because the range between the dose at which a drug is effective and the dose at which side effects occur is small. [ 2 ]
A therapeutic use exemption (TUE), also known as a temporary use exemption, is a term created in 1991 [1] and refers to an official medical document. The document gives an athlete permission to take a medication listed on the World Anti-Doping Agency’s (WADA) Prohibited List, normally prohibited because its use would be considered a performance enhancing drug.
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