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HAP1 cells are a cell line of human origin used for biomedical and genetic research. They are near haploid, having one copy of almost every chromosome and are smaller than the average human cell, growing to about 11 micrometers in diameter. [1] HAP1 cells are derived from a line of cancerous cells, which means they are able to divide indefinitely.
CHO cells adhered to a surface, seen under phase-contrast microscopy. Chinese hamster ovary (CHO) cells are a family of immortalized cell lines [1] derived from epithelial cells of the ovary of the Chinese hamster, often used in biological and medical research and commercially in the production of recombinant therapeutic proteins.
This list, containing 488 cell lines, was last updated on 1 December 2016. [c] Cellosaurus also is maintaining a list of "problematic" cell lines. [6] The list is dynamically generated from all cell lines in the database with a comment containing the dedicated words "Problematic cell line". As of 17 January 2017, the list contains 757 entries.
Many methods are used to identify cell lines, including isoenzyme analysis, human lymphocyte antigen (HLA) typing, chromosomal analysis, karyotyping, morphology and STR analysis. [35] One significant cell-line cross contaminant is the immortal HeLa cell line. HeLa contamination was first noted in the early 1960s in non-human culture in the USA.
Primary cell culture is the ex vivo culture of cells freshly obtained from a multicellular organism, as opposed to the culture of immortalized cell lines.In general, primary cell cultures are considered more representative of in vivo tissues than cell lines, and this is recognized legally in some countries such as the UK (Human Tissue Act 2004). [1]
The human genome contains an estimated 100,000 truncated and 4,000 full-length LINE-1 elements. [10] Due to the accumulation of random mutations, the sequence of many LINEs has degenerated to the extent that they are no longer transcribed or translated. Comparisons of LINE DNA sequences can be used to date transposon insertions in the genome.
Pages in category "Human cell lines" The following 95 pages are in this category, out of 95 total. This list may not reflect recent changes. *
LINE1 (an abbreviation of Long interspersed nuclear element-1, also known as L1 and LINE-1) is a family of related class I transposable elements in the DNA of many groups of eukaryotes, including animals and plants, classified with the long interspersed nuclear elements (LINEs). [1]