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The Pauling's book How to Live Longer and Feel Better, [92] first published in 1986, [93] was a bestseller and advocated taking more than 10 grams per day orally, thus approaching the amounts released by the liver directly into the circulation in other mammals: an adult goat, a typical example of a vitamin C–producing animal, will manufacture ...
Dosing of deferoxamine should be determined through consultation with a toxicologist but is typically continuously infused at 15 mg/kg to 35 mg/kg per hour and not exceeding the maximum daily dose of 6 grams for adults. [3] In pediatric patients, doses should not exceed 15 mg/kg per hour.
Supplements may only contain dosages of 21 mg/day. [45] European Food Safety Authority: 12 mg/day [25] Ministry of Health, Labour and Welfare (厚生労働省, Kōsei-rōdō-shō) Japan 40–60 mg/day The adult UL was set at 40–45 mg/day for women and 50–60 mg/day for men, with the lower values in those ranges for adults over 70 years of age
For instance, if the ADI is based on data from humans the safety factor is usually 10 instead of 100. The ADI is usually given in mg per kg body weight. [5] The ADI is considered a safe intake level for a healthy adult of normal weight who consumes an average daily amount of the substance in question.
34 000 - 60 000 750 000 150 000 150 000 Maximum approved dosage (mg) 100 100 125 200 510 20 mg per kg 1000 mg if patient weight is > 66 kg Test dose required Yes Yes No No No No No Iron concentration (mg/mL) 50 50 12.5 20 30 100 50
In toxicology, the median lethal dose, LD 50 (abbreviation for "lethal dose, 50%"), LC 50 (lethal concentration, 50%) or LCt 50 is a toxic unit that measures the lethal dose of a given substance. [1] The value of LD 50 for a substance is the dose required to kill half the members of a tested population after a specified test duration.
Since iron stores in the body are generally depleted, and there is a limit to what the body can process (about 2–6 mg/kg of body mass per day; i.e. for a 100 kg/220 lb man this is equal to a maximum dose of 200–600 mg/per day) without iron poisoning, this is a chronic therapy which may take 3–6 months. [50]
The median lethal dose, LD 50 (abbreviation for "lethal dose, 50%"), LC 50 (lethal concentration, 50%) or LCt 50 (lethal concentration and time) of a toxin, radiation, or pathogen is the dose required to kill half the members of a tested population after a specified test duration.
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