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The most distinctive sign of bubonic plague is extreme swelling of one or more lymph nodes that bulge out of the skin as "buboes." The buboes often become necrotic and may even rupture. [5] Infectious mononucleosis is an acute viral infection usually caused by Epstein-Barr virus and may be characterized by a marked enlargement of the cervical ...
Lymph nodes may become enlarged in malignant disease. This cervical lymphadenopathy may be reactive or metastatic. [1] Alternatively, enlarged lymph nodes may represent a primary malignancy of the lymphatic system itself, such as lymphoma (both Hodgkin's and non-Hodgkin's), [6] lymphocytic leukemia, [1] Lymphadenopathy that lasts less than two weeks or more than one year with no progressive ...
Lymph node enlargement or swelling is known as lymphadenopathy. [27] Swelling may be due to many causes, including infections , tumors , autoimmune disease , drug reactions , diseases such as amyloidosis and sarcoidosis , or because of lymphoma or leukemia .
Usually this is localized (for example, an infected spot on the scalp will cause lymph nodes in the neck on that same side to swell). However, when two or more lymph node groups are involved, it is called generalized lymphadenopathy. Usually this is in response to significant systemic disease and will subside once the person has recovered.
The presence of swollen inguinal lymph nodes is an important clinical sign because lymphadenopathy (swelling) may indicate an infection, or spread as a metastasis from cancers, such as anal cancer and vulvar cancer. Inguinal lymph nodes may normally be up to 2 cm. [1] The cut-off value for normal sized inguinal nodes is up to 10 mm. [6]
Paracortical hyperplasia is the preferential stimulation of the T cell compartment. It is caused by an abnormal expansion of the interfollicular zones but is confined within the lymph node capsule. The population of the compartment is cytologically polymorphous. Paracortical hyperplasia may be accompanied by vascular proliferation.