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Extremely high levels of unconjugated bilirubin in plasma enables bilirubin to cross the blood-brain-barrier to reach the brain and central nervous system to impart damage. This is termed kernicterus, or bilirubin encephalopathy. Kernicterus is rare in adults but is prevalent in newborns with underdeveloped blood-brain barriers and lower ...
What is the highest billirubin ever recorded for someone with gilberts, mine has been up to 179 mmol/dl --Dr. B Mine reached 7 mg/dl — Preceding unsigned comment added by 2600:4040:2BCD:0:F02A:EC83:6DD6:90FD 22:16, 17 February 2023 (UTC)
Bilirubin (BR) (from the Latin for "red bile") is a red-orange compound that occurs in the normal catabolic pathway that breaks down heme in vertebrates.This catabolism is a necessary process in the body's clearance of waste products that arise from the destruction of aged or abnormal red blood cells. [3]
The bilirubin-UGT enzyme performs a chemical reaction called glucuronidation. Glucuronic acid is transferred to unconjugated bilirubin, which is a yellowish pigment made when your body breaks down old red blood cells, [35] and then being converted to conjugated bilirubin during the reaction. Conjugated bilirubin passes from the liver into the ...
Kernicterus is a bilirubin-induced brain dysfunction. [1] The term was coined in 1904 by Christian Georg Schmorl.Bilirubin is a naturally occurring substance in the body of humans and many other animals, but it is neurotoxic when its concentration in the blood is too high, a condition known as hyperbilirubinemia.
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Jon Brower Minnoch (September 29, 1941 – September 4, 1983) [2] was an American man who is the heaviest recorded human in history, weighing approximately 1,400 lb (635 kilograms; 100 stone) at his peak.
The 60-year-old, whose real name is Darren Taylor, attempted to dive from very high up into a very shallow pool. “I'm gonna do a belly flop into 10 inches of water from 26 feet, 6 inches for a ...