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The antiemetic activity increases with increased dosing; however, side effects also increase, which often limits maximal dosing. [13] For moderate to severe morning sickness and hyperemesis gravidarum: In the UK, Promethazine is the drug of first choice.
An antiemetic is a drug that is effective against vomiting and nausea.Antiemetics are typically used to treat motion sickness and the side effects of opioid analgesics, general anaesthetics, and chemotherapy directed against cancer.
Doxylamine is also a potent anticholinergic, meaning that it causes delirum at high doses—i.e., at much higher doses than recommended. [8] (Specifically it is an antagonist of the muscarinic acetylcholine receptors M 1 through M 5.) These sedative and deliriant effects have in some cases led to using the drug recreationally.
Treatments include anti-sickness medicines and steroids, but some women may require hospitalisation and intravenous fluids. Sir Stephen added: “The more sensitive she is to this hormone, the ...
Dose a Time to peak Half-life b Metabolism Anticholinergic Diphenhydramine: 50 mg 2–3 hours 2–9 hours CYP2D6, others Yes Doxylamine: 25 mg 2–3 hours 10–12 hours CYP2D6, others Yes Hydroxyzine: 25–100 mg 2 hours 20 hours ADH, CYP3A4, others No Doxepin: 3–6 mg 2–3 hours 17 hours c: CYP2D6, others No (at low doses) Mirtazapine: 7.5 ...
The cause of morning sickness is unknown but may relate to changing levels of estrogen and the hormone human chorionic gonadotropin. [2] [9] Some have proposed that morning sickness may be useful from an evolutionary point of view -it may protect both the pregnant woman and the developing embryo just when the fetus is most vulnerable. [1]
Pyridoxine/doxylamine, sold under the brand name Diclectin among others, is a combination of pyridoxine hydrochloride (vitamin B 6) and doxylamine succinate.It is generally used for nausea and vomiting of pregnancy (morning sickness); even though its efficacy has not been proven and subsequent research has led to the removal of recommendations in medical journals.
Pipamazine (INN; trade names Mornidine, Mometine, Nausidol) is a drug of the phenothiazine class formerly used as an antiemetic.It is chemically related to chlorpromazine, but has negligible antipsychotic activity and produces few extrapyramidal side effects.