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Sinus node dysfunction (SND), also known as sick sinus syndrome (SSS), is a group of abnormal heart rhythms (arrhythmias) usually caused by a malfunction of the sinus node, the heart's primary pacemaker. [1] [2] Tachycardia-bradycardia syndrome is a variant of sick sinus syndrome in which the arrhythmia alternates between fast and slow heart ...
Studies have shown that patients with Pacemaker syndrome and/or with sick sinus syndrome are at higher risk of developing fatal complications that calls for the patients to be carefully monitored in the ICU. Complications include atrial fibrillation, thrombo-embolic events, and heart failure. [7]
Currently the treatment for sick sinus syndrome is to remove the SA nodal cells that are not functioning properly (?) and to implant an electronic pacemaker to maintain a regular rhythm. [3] The Tbx18 gene is required for development of pacemaker cells in the heart during fetal development but is normally not functional after birth. [4]
This sinus rhythm is important because it ensures that the heart's atria reliably contract before the ventricles, ensuring as optimal stroke volume and cardiac output. [ 4 ] In junctional rhythm, however, the sinoatrial node does not control the heart's rhythm – this can happen in the case of a block in conduction somewhere along the pathway ...
Sinus node dysfunction also known as sick sinus syndrome is a group of irregular heartbeat conditions caused by faulty electrical signals of the heart. When the heart's sinoatrial node is defective, the heart's rhythms become abnormal—typically too slow or exhibiting pauses in its function or a combination, and very rarely faster than normal.
Ivabradine is contraindicated in sick sinus syndrome. It should also not be used concomitantly with potent inhibitors of CYP3A4, including azole antifungals (such as ketoconazole), macrolide antibiotics, nefazodone and the antiretroviral drugs nelfinavir and ritonavir. [12] Use of ivabradine with verapamil or diltiazem is contraindicated. [13]
Sinus bradycardia is commonly seen in normal healthy persons and athletes in the absence of pathophysiological diseases or conditions. [1] Different factors or etiologies could lead to the dysfunction of the sinus node, causing a malformation or prolongation of the impulse. In terms of pathophysiological diseases, sinus rhythm may be caused by:
Wandering atrial pacemaker may be seen in young, healthy individuals as well as in the elderly and those with lung disease. [2] The cause of wandering atrial pacemaker is unclear. Increased tone from the vagus nerve may factor into the rhythm appearing in young, healthy individuals who exercise. The vagus nerve is a part of the parasympathetic ...
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