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Chondroitin sulfate is an important structural component of cartilage, [2] and provides much of its resistance to compression. [3] Along with glucosamine, chondroitin sulfate has become a widely used dietary supplement for treatment of osteoarthritis, although large clinical trials failed to demonstrate any symptomatic benefit of chondroitin.
Chondroitin sulfate proteoglycans (CSPGs) are proteoglycans consisting of a protein core and a chondroitin sulfate side chain. They are known to be structural components of a variety of human tissues, including cartilage, and also play key roles in neural development and glial scar formation. They are known to be involved in certain cell ...
A chondroitin is a chondrin derivative. [1] Types include: Chondroitin sulfate. Dermatan sulfate. Chondroitin as a supplement is now commonly used (often in combination with glucosamine) in treating the joint disease of osteoarthritis. [2] In contrast to the symptomatic treatments, chondroitin can modify the progression of a disease process in ...
Glycosaminoglycan. The repeating disaccharide unit (GlcUA (1β→3)GalNAc (1β→4)) n of chondroitin sulfate. For polysaccharide nomenclature see here. R 1, R 2, R 3 may have different values. Glycosaminoglycans[1] (GAGs) or mucopolysaccharides[2] are long, linear polysaccharides consisting of repeating disaccharide units (i.e. two-sugar units).
Proteoglycans are proteins [1] that are heavily glycosylated. The basic proteoglycan unit consists of a "core protein " with one or more covalently attached glycosaminoglycan (GAG) chain (s). [2] The point of attachment is a serine (Ser) residue to which the glycosaminoglycan is joined through a tetrasaccharide bridge (e.g. chondroitin sulfate ...
Chondrocyte. Light micrograph of undecalcified hyaline cartilage showing its chondrocytes and organelles, lacunae and matrix. Chondrocytes (/ ˈkɒndrəsaɪt, - droʊ -/, [1] from Greek χόνδρος (chondros) 'cartilage' and κύτος (kytos) 'cell') are the only cells found in healthy cartilage. They produce and maintain the cartilaginous ...
In enzymology, a chondroitin 6-sulfotransferase ( EC 2.8.2.17) is an enzyme that catalyzes the chemical reaction. Thus, the two substrates of this enzyme are 3'-phosphoadenylyl sulfate and chondroitin, whereas its two products are adenosine 3',5'-bisphosphate and Chondroitin 6-sulfate . This enzyme belongs to the family of transferases ...
The systematic name of this enzyme class is N-acetyl-D-galactosamine-6-sulfate 6-sulfohydrolase. Other names in common use include chondroitin sulfatase, chondroitinase, galactose-6-sulfate sulfatase, acetylgalactosamine 6-sulfatase, N-acetylgalactosamine-6-sulfate sulfatase, and N-acetylgalactosamine 6-sulfatase.