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Valve interstitial cells (VIC), cardiac valve interstitial cells, or also known as valvular interstitial cells (VICs), are the most prevalent cells in the heart valve leaflets, which are a type of mesenchymal stem cells (MSCs) and are responsible for maintaining the extracellular matrix that provides the mechanical properties of the heart valve.
Interstitial fibrosis, which is unspecific, and has been described in congestive heart failure, hypertension, and normal aging. [2] Subepicardial fibrosis, also unspecific, and is associated with non-infarction diagnoses such as myocarditis and non-ischemic cardiomyopathy. [3] [4] Replacement fibrosis, which indicates an older infarction. [2]
Mutations in the intercalated disc gene are responsible for various cardiomyopathies that can lead to heart failure. [2] Ruptured intercalated discs, in this case regarded as a visual artifact. Ruptured intercalated discs, when seen on histopathology, have two main causes: Microtome sectioning, thereby being a visual artifact. [4]
The composition and chemical properties of the interstitial fluid vary among organs and undergo changes in chemical composition during normal function, as well as during body growth, conditions of inflammation, and development of diseases, [2] as in heart failure [5] and chronic kidney disease. [6]
Cardiac physiology or heart function is the study of healthy, unimpaired function of the heart: involving blood flow; myocardium structure; the electrical conduction system of the heart; the cardiac cycle and cardiac output and how these interact and depend on one another.
Claude Bernard, French physician who introduced the concept of homeostasis. The human body and even its individual body fluids may be conceptually divided into various fluid compartments, which, although not literally anatomic compartments, do represent a real division in terms of how portions of the body's water, solutes, and suspended elements are segregated.
In cardiology, aortic valve area calculation is an indirect method of determining the area of the aortic valve of the heart. The calculated aortic valve orifice area is currently one of the measures for evaluating the severity of aortic stenosis. A valve area of less than 1.0 cm 2 is considered to be severe aortic stenosis. [1] [2]
A heart valve is a biological one-way valve that allows blood to flow in one direction through the chambers of the heart. A mammalian heart usually has four valves. Together, the valves determine the direction of blood flow through the heart. Heart valves are opened or closed by a difference in blood pressure on each side. [1] [2] [3]
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