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Epileptogenesis is the gradual process by which a typical brain develops epilepsy. [1] Epilepsy is a chronic condition in which seizures occur. [2] These changes to the brain occasionally cause neurons to fire in an abnormal, hypersynchronous manner, known as a seizure. [3]
There are many causes of seizures. Organ failure, medication and medication withdrawal, cancer, imbalance of electrolytes, hypertensive encephalopathy , may be some of its potential causes. [ 2 ] The factors that lead to a seizure are often complex and it may not be possible to determine what causes a particular seizure, what causes it to ...
Epileptogenesis may occur rapidly, further narrowing this window, but a delayed process known as "secondary epileptogenesis" can influence the progression and severity of epilepsy, offering opportunities for intervention even after its onset. Current research focuses on identifying methods and targets to prevent or slow epilepsy development.
Animal models of epilepsy have helped to advance the understanding of how normal brains develop epilepsy (a process known as Epileptogenesis), and have been used in pre-clinical trials of antiepileptic drugs. [1] Epilepsy is a set of syndromes which have in common a predisposition to recurrent epileptic seizures. [2]
For most patients with epilepsy, the risk of passing the disease to a child is only slightly higher than the risk of a member of the general population having a child with epilepsy (1–2%). Specifically, the hereditary rates for patients with: Any type of epilepsy is 3.5–6%; Focal epilepsy is 1–5%; Generalized epilepsy is 6–8%. [5]
Further research by Goddard on the characteristics of the kindling phenomenon led to his conclusion that kindling can be used to model human epileptogenesis, learning and memory. [9] The publication of these results opened a completely new niche for epilepsy research and has stimulated a significant number of studies on the subject of kindling ...
Dravet syndrome (DS), previously known as severe myoclonic epilepsy of infancy (SMEI), is an autosomal dominant genetic disorder which causes a catastrophic form of epilepsy, with prolonged seizures that are often triggered by hot temperatures or fever. [1] It is very difficult to treat with anticonvulsant medications.
This rare epilepsy has a wide age range of presentation (from the first year of life through the early teens). This epilepsy is characterized by absence seizures concurrent with myoclonic jerks, typically occurring several times daily. The genetics of this disorder have not been delineated. Seizures from this disorder often cease within 5 years.