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Iron deficiency, or sideropenia, is the state in which a body lacks enough iron to supply its needs. Iron is present in all cells in the human body and has several vital functions, such as carrying oxygen to the tissues from the lungs as a key component of the hemoglobin protein, acting as a transport medium for electrons within the cells in the form of cytochromes, and facilitating oxygen ...
Since iron stores in the body are generally depleted, and there is a limit to what the body can process (about 2–6 mg/kg of body mass per day; i.e. for a 100 kg/220 lb man this is equal to a maximum dose of 200–600 mg/per day) without iron poisoning, this is a chronic therapy which may take 3–6 months. [50]
Iron-deficiency anemia is anemia caused by a lack of iron. [3] Anemia is defined as a decrease in the number of red blood cells or the amount of hemoglobin in the blood. [3] When onset is slow, symptoms are often vague such as feeling tired, weak, short of breath, or having decreased ability to exercise. [1]
Iron poisoning can occur when doses of 20 to 60 mg/kg or more of elemental iron is ingested with most cases reporting primarily gastrointestinal symptoms. [4] Systemic signs and symptoms shown in serious toxicity occur at higher doses exceeding 60 mg/kg. [5] Ingesting above 120 mg/kg may be fatal. [4]
220 mg (44 mg iron) per 5 mL* Ferrous Sulfate Elixir: 300 mg (60 mg iron) per 5 mL: Ferrous Sulfate Solution: 125 mg (25 mg iron) per mL* Fer-Gen-Sol® Drops: Teva Fer-In-Sol® Drops: Mead Johnson Tablets: 195 mg (39 mg iron)* Mol-Iron® Schering-Plough 300 mg (60 mg iron)* Feratab® Upsher-Smith 325 mg (65 mg iron)* Tablet, enteric-coated
IV iron infusions are administered to patients who cannot use oral supplementation to treat their deficiency, or if oral treatment has proven ineffective. [8] Oral iron supplementations are the first line of care for iron deficiency and iron deficiency anaemia. Anaemic patients are treated with iron tablets containing 100 mg to 200 mg of iron. [7]
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