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Polypyrimidine tract-binding protein, also known as PTB or hnRNP I, is an RNA-binding protein. PTB functions mainly as a splicing regulator, although it is also involved in alternative 3' end processing, mRNA stability and RNA localization. [ 1 ]
PTBP1 has been shown to interact with HNRPK, [9] PCBP2, [9] SFPQ [10] [11] and HNRNPL. [9] [12]This gene is targeted by the microRNA miR-124.During neuronal differentiation, miR-124 reduces PTBP1 levels, leading to the accumulation of correctly spliced PTBP2 mRNA and a dramatic increase in PTBP2 protein.
The PTB domains facilitate interaction with the activated tyrosine-phosphorylated insulin receptor. The PTB domain is situated towards the N terminus . Two arginines in this domain are responsible for hydrogen bonding phosphotyrosine residues on an Ac -LYASSNPApY- NH2 peptide in the juxtamembrane region of the insulin receptor.
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3667 16367 Ensembl ENSG00000169047 ENSMUSG00000055980 UniProt P35568 P35569 RefSeq (mRNA) NM_005544 NM_010570 RefSeq (protein) NP_005535 NP_034700 Location (UCSC) Chr 2: 226.73 – 226.8 Mb Chr 1: 82.21 – 82.27 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Insulin receptor substrate 1 (IRS-1) is a signaling adapter protein that in humans is encoded by the IRS1 gene. It is a 180 ...
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Benjamin Charles Gruenberg (15 August 1875 – 1 July 1965) was a Russian-born American biology educator and writer. He was involved in establishing high school biology curricula for New York high schools and sex education in the United States.
Pier Giorgio Righetti (born 25 April 1941, Forlì, Northern Italy) [1] is a professor emeritus of chemistry. He worked primarily at the University of Milano (1971-1995) and at the Department of Chemistry of the Politecnico di Milano in Milan, Italy (2005-2011).